<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1270 1270-30923 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M Q58E L10V, L63P, I66V, H69R, I72IT, T74K, L89M, Q92K, I93M, C95F  
>1270-30923| codons 1-99
PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD
QIPIEVCGRKATGKVLVGPTPVNVIGRNMMTKMGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74IV, M184V, T215F K219Q Y181C, G190A   K20KR, V35L, T39A, K43KE, A98S, K101Q, K122E, D123S, S162D, H208Y, R211K, D218E, L228H, Q242H, A272P, V292I, I293V, P294T, Q334P, M357S, A376T, T386TS, K390R  
>1270-30923| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEEGKISKIGPENPYNTPV
FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLQKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI
CQYVDDLYVASDLEIGQHRTKIEELRQYLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGPGQWTYQIYQEPFKNLKTGKYARSRGA
HTNDVKQLTEAVQKITTESIVIWGKSPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006