Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1269 | 1269-30814 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | A62V, K219N | G190A | P4PS, K43E, E44A, K102Q, V118I, D123E, I142V, T165I, I178IM, V179I, R211K, V245E, K277R, I293V, E297K, E312V, R356K, M357KR, R358K, G359S, A371V, T377L, T386TI, E399D |
| >1269-30814| codons 1-400 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FVIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDMII YQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKVPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKRKSA HTNDVKQLTEVVQKIALESIVIWGKIPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82A | K43T | L10I, I13V, K20IM, E35ED, M36I, N37D, I62V, L63S, I64V, H69Y, I72IV |
| >1269-30814| codons 1-99 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEDIDLPGRWTPKMIVGIGGFAKVRQYD QVSVEICGYKAVGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |