Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1259 | 1259-40720 | Belgium | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 57 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | N83D | L10I, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93L | T31TA |
| >1259-40720| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDAVLQELDWPGRWKPKMIGGIGGFVKVKQYD QVPIEICGHKVIGTVLVGPTPVDVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219R | K101E, Y181I, Y188L, G190A | T39K, K43E, E44D, V60I, V118I, K122E, I135T, G196E, E203K, Q207E, R211A, K223Q, V245A, K277R, I293V, E297K, G333E, Q334H, R358K, G359S, T386TI, K390R |
| >1259-40720| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI IQYVDDLLVASDLEIEQHRTKIKELREHLWAWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIALPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |