<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1259 1259-31208 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 25

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y K219R K101E, Y181I, Y188L, G190A   T39K, K43E, E44D, V60I, V118I, K122E, I135T, G196E, E203K, Q207E, R211A, K223Q, V245A, K277R, I293V, E297K, E298EK, G333E, Q334H, R358K, G359S, K390R  
>1259-31208| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPI
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
IQYVDDLLVASDLEIEQHRTKIKELREHLWAWGFYTPDRKHQQEPPFLWMGYELHPDKWT
VQPIALPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKKAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M N83D L10I, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93L  
>1259-31208| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLQELDWPGRWKPKMIGGIGGFVKVKQYD
QVPIEICGHKVIGTVLVGPTPVDVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006