Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1258 | 1258-30610 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A, L90M | F53L | L10I, K20KR, M36MI, I62V, L63P, I64V, H69HY, A71AT, T74S, V77VI, I85V | T91TCS |
| >1258-30610| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEINLPGRWKPKMIMGIGGLVKVRQYD QVPVEICGYKTIGSVLIGPTPANIVGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, M184I, L210W, T215Y | A62V | K101E, Y181C, G190A | A98G | V35VI, K43E, K49R, K122E, R211RK, A272P, R356K, K366R, T386I |
| >1258-30610| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEEEGKISRIGPENPYNTPV FVIKKKDSGKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYIDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |