Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1257 | 1257-30526 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, G73T | N37D, R57K, L63P, A71V, I93L |
| >1257-30526| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIVGGIGGFVKVKQYD QIPIEICGHKVITTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | A62V | K103N, Y181C, G190A | A98G | K43KE, E44D, V111I, V118I, D123E, I135T, S163SC, T165TI, I178L, E203A, Q207E, H208Y, R211K, H221C, L228H, A272P, K277R, T286A, E297K, Q334L, R356K, M357T, G359S, A360V, V365I, T377M |
| >1257-30526| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV FVIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDIGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSCMIKILEPFRKQNPDLVI CQYVDDLYVASDLEIGQHRTKIAELREYLWKWGFYTPDKKCQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKTRSV HTNDIKQLTEAVQKIAMESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |