Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1256 | 1256-30515 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219Q | Y181C | K20R, E44D, V60I, T69N, I135T, D177E, G196E, E203V, Q207E, H208Y, R211K, K223Q, L228H, V245T, K277R, Q278H, I293V, I329L, G335D, R356K, G359S, A376C, T386I, K390R, E396EG |
| >1256-30515| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIEQHRTKIVELREYLWKWGFYTPDQKHQQEPPFHWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKICTESIVIWGKIPKFRLPIQKGTWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, L33F, K43T, F53L | T4P, I13V, I15V, L19LI, K20R, L24F, E35D, M36I, R41K, L63P, A71I, Q92K, I93L |
| >1256-30515| codons 1-99 PQIPLWQRPFVTVKVGGQIREALFDTGADDTVFEDINLPGKWTPKLIGGIGGLVKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |