<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1256 1256-30515 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219Q Y181C   K20R, E44D, V60I, T69N, I135T, D177E, G196E, E203V, Q207E, H208Y, R211K, K223Q, L228H, V245T, K277R, Q278H, I293V, I329L, G335D, R356K, G359S, A376C, T386I, K390R, E396EG  
>1256-30515| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYMDDLYVGSDLEIEQHRTKIVELREYLWKWGFYTPDQKHQQEPPFHWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKICTESIVIWGKIPKFRLPIQKGTWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L10F, L33F, K43T, F53L T4P, I13V, I15V, L19LI, K20R, L24F, E35D, M36I, R41K, L63P, A71I, Q92K, I93L  
>1256-30515| codons 1-99
PQIPLWQRPFVTVKVGGQIREALFDTGADDTVFEDINLPGKWTPKLIGGIGGLVKVRQYD
QIPIEICGHKIIGTVLVGPTPANIIGRNLMTKLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006