Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1254 | 1254-30617 | Belgium | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V | L33F, N83D | L10LI, I13V, E35D, M36V, N37NS, P39T, R41K, R57K, L63S, H69K, L89M |
| >1254-30617| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEDVSLTGKWKPKMIVGIGGFIKVKQYD QISIEICGKKAIGTVLVGPTPVDIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | V35T, T39A, E40D, K122E, D123N, I135T, K173S, D177E, V179I, T200A, Q207A, R211K, F214L, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, I326T, G335D, M357K, R358K, G359S, K366R, A371V, I375V, A376V, V381I, K390R |
| >1254-30617| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICADMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSQNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRAHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLTAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKKSA HTNDVRQLTEVVQKVVTESIIIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |