<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1253 1253-30605 Belgium 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    Y181C   V35T, K49R, I50IV, V60I, K122E, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211S, D218DE, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334HR, G335D, M357K, R358G, G359S, K366R, E370A, A371V, I375V, T377M  
>1253-30605| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRVGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPEMII
CQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPEKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGRDQWTYQIYQEPFKNLKTGKYARKGSA
HTNDVRQLTAVVQKVAMESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89M  
>1253-30605| codons 1-99
PQITLWQRPVVPVRIEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
EVSIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006