Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1253 | 1253-30605 | Belgium | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, T12TP, I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57RK, Q61QE, I62IV, L63CS, H69K, L89M |
| >1253-30605| codons 1-99 PQITLWQRPVVPVRIEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD EVSIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y181C | V35T, K49R, I50IV, V60I, K122E, K173L, Q174K, D177E, I178IM, V179I, T200A, Q207A, R211S, D218DE, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334HR, G335D, M357K, R358G, G359S, K366R, E370A, A371V, I375V, T377M |
| >1253-30605| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRVGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPEMII CQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPEKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGRDQWTYQIYQEPFKNLKTGKYARKGSA HTNDVRQLTAVVQKVAMESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |