<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1252 1252-30605 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y K219R   A98G P4PS, V35M, T39KR, K43E, E44D, V118I, S162SN, Q174E, G196E, E203V, Q207E, R211K, A272P, K281R, A288S, V292I, I293V, P294T, E297K, Q334L, G335S, A360T, K366R, T369V, A371V, I375V, A376T, T386I, K390R  
>1252-30605| codons 1-399
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICRELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKENPDIVI
YQYVDDLYVGSDLEIEQHRTKIVELREHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKSLTEIVTLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVRQLVEVVQKVTTESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50V, I54A, V82A L33F L10I, N37D, I62V, L63T, H69Y, A71V, V77I, I93L  
>1252-30605| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMDLPGRWKPKMIVGVGGFAKVRQYD
QVTIEICGYKVIGTVLIGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006