Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1252 | 1252-30605 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | A98G | P4PS, V35M, T39KR, K43E, E44D, V118I, S162SN, Q174E, G196E, E203V, Q207E, R211K, A272P, K281R, A288S, V292I, I293V, P294T, E297K, Q334L, G335S, A360T, K366R, T369V, A371V, I375V, A376T, T386I, K390R |
| >1252-30605| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICRELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKENPDIVI YQYVDDLYVGSDLEIEQHRTKIVELREHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKSLTEIVTLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLVEVVQKVTTESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A | L33F | L10I, N37D, I62V, L63T, H69Y, A71V, V77I, I93L |
| >1252-30605| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMDLPGRWKPKMIVGVGGFAKVRQYD QVTIEICGYKVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |