<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1251 1251-30602 Belgium 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y V75M K101E, G190A A98G E28K, K32E, V35T, T39A, E44D, V60I, V118I, K122E, I135V, S162C, K173T, Q174K, N175Y, D177E, T200A, E203D, Q207K, R211EK, K223Q, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, V317A, D324E, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, S379A, I382M, Q394R, K395R  
>1251-30602| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKYPEIVI
YQYMDDLYVASDLEIGQHRAKIDELRKHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGAYYDPSKELIAEVQKQGLDQWTYQIYQEPYKNLKTGKYAKRGSA
HTNDVKQLTEVVQKIATEAIVMWGKTPKFKLPIRRETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V, L90M L89V L10I, I13V, K20I, E35D, M36I, N37D, R41K, K55N, I62V, L63P, C67F, H69K, A71V, T74S  
>1251-30602| codons 1-99
PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEDIDLPGKWKPKIIGGIGGFVNVRQYD
QVPIEIFGKKVIGSVLVGPTPTNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006