Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1251 | 1251-30602 | Belgium | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, L210W, T215Y | K101E, G190A | A98G | E28K, K32E, V35T, T39A, E44D, V60I, V118I, K122E, I135V, S162C, K173T, Q174K, N175Y, D177E, T200A, E203D, Q207K, R211EK, K223Q, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, V317A, D324E, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, S379A, I382M, Q394R, K395R |
| >1251-30602| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKYPEIVI YQYMDDLYVASDLEIGQHRAKIDELRKHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGAYYDPSKELIAEVQKQGLDQWTYQIYQEPYKNLKTGKYAKRGSA HTNDVKQLTEVVQKIATEAIVMWGKTPKFKLPIRRETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V, L90M | L89V | L10I, I13V, K20I, E35D, M36I, N37D, R41K, K55N, I62V, L63P, C67F, H69K, A71V, T74S |
| >1251-30602| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEDIDLPGKWKPKIIGGIGGFVNVRQYD QVPIEIFGKKVIGSVLVGPTPTNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |