Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1250 | 1250-31215 | Belgium | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90LM | L10I, E35D, M36I, R41K, Q61HN, I62V, L63R, K70E | L89LW |
| >1250-31215| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD NVRIEICGHEAIGTVLVGPTPVNIIGRNWMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69TADN | T215C, K219Q | K103N | P4T, V35T, V60I, K104KN, V118I, D121H, K122E, I135T, Q174R, D177E, I178L, Q207E, R211K, F214L, V245T, D250E, A272P, T286A, A288T, E297A, I329L, G335D, R356K, G359NS, V365I, A376S, T386I, K390R |
| >1250-31215| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNNSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPELVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGLCTPDQKHQKEPPFLWMGYELHPDKWT VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYAKMRSA HTNDIKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |