<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1249 1249-30519 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y V75VA, K219R V106A, G190A F227L V35T, T39A, E44D, S105ST, V118I, K122E, D123E, I142V, D177E, I178L, V179I, G196E, E203V, Q207E, H208Y, R211K, K223Q, A272P, K281R, T286A, E297K, K323KQ, D324DE, R358K, G359S, A371V, T377L, I382T, E396D  
>1249-30519| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVADFRELNKRTQDFWEVQLGIPHPAGLKKKKTATVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELII
YQYVDDLYVASDLEIEQHRTKIVELREYLWKWGFYTPDRKHQQEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSQELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVKQLTEVVQKIALESIVTWGKTPKFKLPIQKDTWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, V11VI, L33F, F53LW, G73S E34EQ, N37D, K55R, L63P, C67F, A71V, I72L, V77I, I85V, T91S  
>1249-30519| codons 1-99
PQITLWQRPFITIKIGGQLKEALLDTGADDTVFQEMDLPGRWKPKIIGGIGGWVRVRQYD
QIPIEIFGHKVLSTVLIGPTPVNVVGRNLMSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006