Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1249 | 1249-30519 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11VI, L33F, F53LW, G73S | E34EQ, N37D, K55R, L63P, C67F, A71V, I72L, V77I, I85V, T91S |
| >1249-30519| codons 1-99 PQITLWQRPFITIKIGGQLKEALLDTGADDTVFQEMDLPGRWKPKIIGGIGGWVRVRQYD QIPIEIFGHKVLSTVLIGPTPVNVVGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | V75VA, K219R | V106A, G190A | F227L | V35T, T39A, E44D, S105ST, V118I, K122E, D123E, I142V, D177E, I178L, V179I, G196E, E203V, Q207E, H208Y, R211K, K223Q, A272P, K281R, T286A, E297K, K323KQ, D324DE, R358K, G359S, A371V, T377L, I382T, E396D |
| >1249-30519| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVADFRELNKRTQDFWEVQLGIPHPAGLKKKKTATVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELII YQYVDDLYVASDLEIEQHRTKIVELREYLWKWGFYTPDRKHQQEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSQELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEVVQKIALESIVTWGKTPKFKLPIQKDTWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |