<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1248 1248-30623 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, L90M L33I, K43T, G73S, N88G L10I, L19LV, K20R, E35D, M36I, N37DE, K55R, I62V, L63P, A71V, I72V, V75I, I85V  
>1248-30623| codons 1-99
PQITLWQRPIVTIKIGGQVREALLDTGADDTVIEDIELPGRWTPKIIGGIGGFVRVRQYD
QVPIEICGHKVVSTILVGPTPTNIVGRGLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y D67H, T69G, K219N K101E, Y181C, G190A A98AG, V108I T7TP, V35IM, T39A, D86DE, W88C, V118I, K122E, D123T, D177E, I178L, V179T, E203K, Q207D, H208Y, R211RK, H221Y, A272P, K277R, I293V, E297A, S322T, D324E, I329V, G333E, K350KR, K366R, T386I, K390R, K395R, E399D  
>1248-30623| codons 1-399
PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV
FAIKKKHSGKWRKVVDFRELNKRTQEFCEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL
DETFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELTI
CQYVDDLYVASDLEIGQHRTKIKELRDYLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPTKELIAEVQKQEQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006