Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1248 | 1248-30623 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | L33I, K43T, G73S, N88G | L10I, L19LV, K20R, E35D, M36I, N37DE, K55R, I62V, L63P, A71V, I72V, V75I, I85V |
| >1248-30623| codons 1-99 PQITLWQRPIVTIKIGGQVREALLDTGADDTVIEDIELPGRWTPKIIGGIGGFVRVRQYD QVPIEICGHKVVSTILVGPTPTNIVGRGLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67H, T69G, K219N | K101E, Y181C, G190A | A98AG, V108I | T7TP, V35IM, T39A, D86DE, W88C, V118I, K122E, D123T, D177E, I178L, V179T, E203K, Q207D, H208Y, R211RK, H221Y, A272P, K277R, I293V, E297A, S322T, D324E, I329V, G333E, K350KR, K366R, T386I, K390R, K395R, E399D |
| >1248-30623| codons 1-399 PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKHSGKWRKVVDFRELNKRTQEFCEVQLGIPHPGGLEKKKSVTILDVGDAYFSIPL DETFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELTI CQYVDDLYVASDLEIGQHRTKIKELRDYLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPTKELIAEVQKQEQGQWTYQIYQEPFKNLRTGKYARMRGA HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |