<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1247 1247-30610 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, L210W, T215Y V75M, K219Q   V179E K20R, V21I, T27S, T39K, K43E, E44D, K49KR, V60I, V118I, D123E, I135T, E203D, H208Y, R211K, D218E, L228H, K277R, I293V, V317A, I329V, E344D, P345L, M357MR, R358K, A371V, T377M, S379C, K390R  
>1247-30610| codons 1-400
PISPIETVPVKLKPGMDGPRIKQWPLSEEKIKALVEICKELEEDGKISRIGPENPYNTPI
FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI
YQYVDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQGQGQWTYQIYQDLFKNLKTGKYARRKGA
HTNDVKQLTEVVQKIAMECIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V L23I, L24I, F53L, Q58E L10I, T12P, L19LI, N37S, I62V, L63Q, I64V, H69R, A71V, V77I, L89M, I93L  
>1247-30610| codons 1-99
PQITLWQRPIVPIKIGGQIKEAIIDTGADDTVLEEMSLPGRWKPKIIGGIGGLVKVREYD
QVQVEICGRKVIGTVVIGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006