Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1247 | 1247-30610 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V | L23I, L24I, F53L, Q58E | L10I, T12P, L19LI, N37S, I62V, L63Q, I64V, H69R, A71V, V77I, L89M, I93L |
| >1247-30610| codons 1-99 PQITLWQRPIVPIKIGGQIKEAIIDTGADDTVLEEMSLPGRWKPKIIGGIGGLVKVREYD QVQVEICGRKVIGTVVIGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219Q | V179E | K20R, V21I, T27S, T39K, K43E, E44D, K49KR, V60I, V118I, D123E, I135T, E203D, H208Y, R211K, D218E, L228H, K277R, I293V, V317A, I329V, E344D, P345L, M357MR, R358K, A371V, T377M, S379C, K390R |
| >1247-30610| codons 1-400 PISPIETVPVKLKPGMDGPRIKQWPLSEEKIKALVEICKELEEDGKISRIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI YQYVDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGQGQWTYQIYQDLFKNLKTGKYARRKGA HTNDVKQLTEVVQKIAMECIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |