Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1246 | 1246-30610 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A | L10F, K43T | I15V, G16A, K20R, M36I, N37D, K55R, Q61E, I62V, L63P, I93L |
| >1246-30610| codons 1-99 PQITLWQRPFVTIKVAGQLREALLDTGADDTILEEIDLPGRWTPKIVGGIGGFMRVRQYD EVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75M, M184V, L210W, T215Y | K103N | K11R, K20R, V35VI, K43E, E44A, K64KN, K73M, V118I, K122E, S162D, T200K, Q207E, R211K, K223Q, V245E, K277R, T286A, V292I, I293V, E297A, M357K, G359S, D364DE, A371V, K390KR | I326W |
| >1246-30610| codons 1-399 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAINKKNSTKWRMIMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRKKIEELREHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLWAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRSA HTNEVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |