<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1246 1246-30610 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A L10F, K43T I15V, G16A, K20R, M36I, N37D, K55R, Q61E, I62V, L63P, I93L  
>1246-30610| codons 1-99
PQITLWQRPFVTIKVAGQLREALLDTGADDTILEEIDLPGRWTPKIVGGIGGFMRVRQYD
EVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, V75M, M184V, L210W, T215Y   K103N   K11R, K20R, V35VI, K43E, E44A, K64KN, K73M, V118I, K122E, S162D, T200K, Q207E, R211K, K223Q, V245E, K277R, T286A, V292I, I293V, E297A, M357K, G359S, D364DE, A371V, K390KR I326W
>1246-30610| codons 1-399
PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAINKKNSTKWRMIMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRKKIEELREHLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLWAEIQKQGQGQWTYQIYQEPFKNLKTGKYARKRSA
HTNEVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006