<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1245 1245-30414 Belgium 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, L90M F53L, G73S L10V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, I62V, L63P, H69HY, A71IV, I72T, I93L  
>1245-30414| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDIDLPGKWKPKIIGGIGGLVRVKQYD
QVPIEICGYKVTSTVLVGPTPTNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y       E28K, V35M, T39A, K43E, A158S, S162Y, K173T, Q174K, N175Y, T200A, E203D, Q207E, R211K, L228H, Q242QH, V245Q, E248D, A272P, K275R, Q278N, L283I, T286A, E291D, V292I, I293V, D324E, R356K, G359S, K366R, T369V, A371V, A376S, T377M, K390R  
>1245-30414| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALMEICAELEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQYSMTKILEPFRTKYPDIVI
YQYVDDLYVGSDLEIGQHRAKIDELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VHPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVKNLCKLIRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVRQLVEVVQKISMESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006