Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1245 | 1245-30414 | Belgium | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | F53L, G73S | L10V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, I62V, L63P, H69HY, A71IV, I72T, I93L |
| >1245-30414| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDIDLPGKWKPKIIGGIGGLVRVKQYD QVPIEICGYKVTSTVLVGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | E28K, V35M, T39A, K43E, A158S, S162Y, K173T, Q174K, N175Y, T200A, E203D, Q207E, R211K, L228H, Q242QH, V245Q, E248D, A272P, K275R, Q278N, L283I, T286A, E291D, V292I, I293V, D324E, R356K, G359S, K366R, T369V, A371V, A376S, T377M, K390R |
| >1245-30414| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQYSMTKILEPFRTKYPDIVI YQYVDDLYVGSDLEIGQHRAKIDELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VHPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVKNLCKLIRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVRQLVEVVQKISMESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |