Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1244 | 1244-30527 | Belgium | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75T, L210W, T215Y | K219D | Y181C, G190A | A98G, V179E | T27S, E28K, K32E, V35T, E36D, T39N, V60I, K64KR, K102Q, V118I, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242H, V245Q, D250E, K281R, T286A, E291D, V292I, I293V, P294T, S322A, G335D, R356K, M357K, G359S, A360AT, A371V, I375V, T386I, K390R, K395R |
| >1244-30527| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSKEKIEALTDICNELEKEGKISKIGPENPYNTPI FAIRKKNSTRWRKLTDFRELNKRTQDFWEVQLGIPHPGGLKQKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEMEI CQYMDDLYVASDLEIGQHRAKIKELREYLWKWGFYTPDDKHQEEPPFHWMGYELHPDKWT VHPIQLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRST HTNDVKQLTEVVQKVATESIVIWGKIPKFRLPIQRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | V11VI, L33F, K43T, F53L | T4A, L10V, I13V, G16A, L19P, K20M, E35D, M36L, K55R, Q61H, L63P, H69K, T74AS, L89I, T91S | E21A |
| >1244-30527| codons 1-99 PQIALWQRPVITVKIAGQPMAALLDTGADDTVFEDLNLPGRWTPKLIGGIGGLVRVRQYD HIPIEICGKKAIGSVLVGPTPANVIGRNILSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |