Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1231 | 1231-30513 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73T | L10I, L19I, K20I, L63P, A71V, I72V, I93L |
| >1231-30513| codons 1-99 PQITLWQRPIVTIKIGGQIIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVVTTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K101E, Y181YC, G190A | V35L, T39A, K43E, E44A, K49R, S117A, V118I, K122E, D177E, V179VI, G196E, H208Y, R211N, V245E, A272P, R284K, T286A, I293IV, P294A, V317A, Q334N, G335N, M357T, T386I, E399G |
| >1231-30513| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEEAGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFAIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYMDDLYVASDLEIEQHRTKIEELRQYLWNWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVVALTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGNNQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWGA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |