<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1230 1230-30508 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T215Y       V60I, K101Q, K104KN, V118VI, K122P, I135IT, E169EK, R172RK, D177EK, V179I, E194EK, T200K, Q207E, R211K, T286A, V292VI, E297K, K311R, I329L, Q334E, A376AV  
>1230-30508| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKNSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFKKQNPKIII
YQYMDDLYVGSDLKIGQHRKKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIIPLTKEAE
LELAENREILREPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKIVTESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, V82A, L90M L33LF L10IV, L19I, K20KR, E35D, M36IL, N37DE, K55N, L63P, A71T, I72R, I93L, C95F  
>1230-30508| codons 1-99
PQITLWQRPVVTIKIGGQIREALLDTGADDTIFEDLELPGRWKPKIVGGIGGFINVRQYD
QIPIEICGHKTRGTVLVGPTPANIIGRNLMTQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006