Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1230 | 1230-30508 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A, L90M | L33LF | L10IV, L19I, K20KR, E35D, M36IL, N37DE, K55N, L63P, A71T, I72R, I93L, C95F |
| >1230-30508| codons 1-99 PQITLWQRPVVTIKIGGQIREALLDTGADDTIFEDLELPGRWKPKIVGGIGGFINVRQYD QIPIEICGHKTRGTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T215Y | V60I, K101Q, K104KN, V118VI, K122P, I135IT, E169EK, R172RK, D177EK, V179I, E194EK, T200K, Q207E, R211K, T286A, V292VI, E297K, K311R, I329L, Q334E, A376AV |
| >1230-30508| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKNSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFKKQNPKIII YQYMDDLYVGSDLKIGQHRKKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIIPLTKEAE LELAENREILREPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIVTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |