<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1229 1229-30428 Belgium 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, V82F, L90M   L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93L  
>1229-30428| codons 1-99
PQITLWQRPIVSVKIGGRIIEALLDTGADDTVLQELNLPGRWKPKIIGGIGGFAKVRQYD
QVPIEICGKKAIGAVLIGPTPFNIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y     A98AG K20R, V35T, T39E, E44D, V118I, D121H, K122E, I135T, K166R, K173T, Q174R, D177E, T200A, E203K, Q207E, H208Y, R211K, V245Q, D250E, A272P, K277R, E291D, V292I, I293V, E297A, Q334D, R356K, G359T, T377L, K390R  
>1229-30428| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTRNPEIVI
YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006