Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1229 | 1229-30428 | Belgium | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82F, L90M | L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93L |
| >1229-30428| codons 1-99 PQITLWQRPIVSVKIGGRIIEALLDTGADDTVLQELNLPGRWKPKIIGGIGGFAKVRQYD QVPIEICGKKAIGAVLIGPTPFNIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | A98AG | K20R, V35T, T39E, E44D, V118I, D121H, K122E, I135T, K166R, K173T, Q174R, D177E, T200A, E203K, Q207E, H208Y, R211K, V245Q, D250E, A272P, K277R, E291D, V292I, I293V, E297A, Q334D, R356K, G359T, T377L, K390R |
| >1229-30428| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTRNPEIVI YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |