<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1226 1226-30417 Belgium 2003 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y V75M, K219E K103S, G190A V108I P4Q, K20R, V35T, T39A, E44D, V60I, V118I, K122E, D123N, I135V, S162A, K173V, Q174K, D177E, I178M, Q197L, T200A, E203V, Q207E, K223Q, L228H, P243T, V245Q, T286A, I293V, P294T, S322A, G335D, M357K, R358K, G359S, A371V, I375V, A376T, T377M, T386A, K390R, E399D  
>1226-30417| codons 1-399
PISQIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTILDVGDAYFSIPL
DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRVKNPEMVI
YQYMDDLYVASDLEIGLHRAKIVELREHLWRWGFYTPDEKHQQEPPFHWMGYELHPDKWT
VQTIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVTLTEEAE
LELAENREILKEPVHGVYYDPAKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKKSA
HTNDVKQLTEVVQKVTMESIVIWGKAPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, L76V, I84A V11I, G73S, L89V L10M, I13V, K14R, I15V, Q18I, K20I, M36I, N37D, R41K, H69K, A71V, T74S  
>1226-30417| codons 1-99
PQITLWQRPMITVRVGGILIEALLDTGADDTVLEEIDLPGKWKPKIVGGIGGFIKVRQYD
QILIEICGKKVISSVVVGPTPVNAIGRNVLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006