Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1225 | 1225-30417 | Belgium | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215CY | K103N | V179VD | V35T, K43E, K49R, V60I, K102Q, V118I, D121C, K122E, E169D, D177E, I178L, Q207E, R211K, P243S, V245K, D250E, A272P, I293V, Q334D, G335S, M357T, G359S, V365I, T369V, S379G, T386I, K390R | V189VIM |
| >1225-30417| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEEEGKISRIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSIPL CEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPELDI YQYMDDLYMGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQSIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDSQWTYQIYQEPFKNLKTGKYARTRSA HTNDIKQLVEAVQKIATEGIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90LM | Q7E, L10I, G16GE, P39S, R41K, D60E, L63P, I64V, V77I, I85IV |
| >1225-30417| codons 1-99 PQITLWERPIVTIKIEGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYE QIPVEICGHKAIGTVLIGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |