<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1225 1225-30417 Belgium 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215CY   K103N V179VD V35T, K43E, K49R, V60I, K102Q, V118I, D121C, K122E, E169D, D177E, I178L, Q207E, R211K, P243S, V245K, D250E, A272P, I293V, Q334D, G335S, M357T, G359S, V365I, T369V, S379G, T386I, K390R V189VIM
>1225-30417| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEEEGKISRIGPENPYNTPI
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSIPL
CEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPELDI
YQYMDDLYMGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQSIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDSQWTYQIYQEPFKNLKTGKYARTRSA
HTNDIKQLVEAVQKIATEGIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90LM   Q7E, L10I, G16GE, P39S, R41K, D60E, L63P, I64V, V77I, I85IV  
>1225-30417| codons 1-99
PQITLWERPIVTIKIEGQLKEALLDTGADDTVLEEMNLSGKWKPKMIGGIGGFIKVRQYE
QIPVEICGHKAIGTVLIGPTPVNVVGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006