Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1218 | 1218-30701 | Belgium | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, G73T | L10V, T12S, I13V, K14T, I15V, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, I62V, L63P, A71T, I72T, I93L |
| >1218-30701| codons 1-99 PQITLWQRPVVSVTVGGQLTEALLDTGADDTVFEDINLTGKWKPKIIGGIGGFVKVKQYD NVPIEICGHKTTTTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219W | P4S, T7P, K20R, V35T, I135T, S162Y, K173T, Q174K, V179I, I202V, H208Y, R211K, L228H, V245Q, A272P, T286A, A288T, E291D, V292I, I293V, E297T, Q334E, R356K, R358K, G359S, T377Q, S379C, K390R, Q394L, K395R, E399D |
| >1218-30701| codons 1-399 PISSIEPVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQYLLKWGFFTPDWKHQKEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMKSA HTNDVKQLTEAVQKIAQECIVIWGKTPKFRLPILRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |