<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1218 1218-30701 Belgium 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, G73T L10V, T12S, I13V, K14T, I15V, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, I62V, L63P, A71T, I72T, I93L  
>1218-30701| codons 1-99
PQITLWQRPVVSVTVGGQLTEALLDTGADDTVFEDINLTGKWKPKIIGGIGGFVKVKQYD
NVPIEICGHKTTTTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, M184V, T215F K219W     P4S, T7P, K20R, V35T, I135T, S162Y, K173T, Q174K, V179I, I202V, H208Y, R211K, L228H, V245Q, A272P, T286A, A288T, E291D, V292I, I293V, E297T, Q334E, R356K, R358K, G359S, T377Q, S379C, K390R, Q394L, K395R, E399D  
>1218-30701| codons 1-399
PISSIEPVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPDIII
YQYVDDLYVGSDLEIGQHRTKVEELRQYLLKWGFFTPDWKHQKEPPFHWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTDIVPLTTEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMKSA
HTNDVKQLTEAVQKIAQECIVIWGKTPKFRLPILRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006