<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1217 1217-30701 Belgium 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V K219E Y181C   I2V, K20R, V35T, T39A, V60I, K102Q, K122E, D123S, I132V, I135R, S162A, K173R, Q174K, T200V, E203K, Q207E, R211E, F214L, D218E, V245Q, E248D, D250E, S251D, A272P, T286A, E291D, V292I, I293V, E297A, I329V, Q334L, F346Y, N348T, R356K, M357R, R358G, G359S, A360T, E370A, A371V, A376S, T386I, K390R, E399D  
>1217-30701| codons 1-399
PVSPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL
DESFRKYTAFTVPSRNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRRKNPDIVI
CQYVDDLYVGSDLEIGQHRVKIKELREHLLEWGLTTPEEKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKEDWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPYKTLKTGKYAKRGST
HTNDVKQLTAVVQKISTESIVIWGKIPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M V11I, F53L L10V, T12K, I13V, K14R, G16E, K20I, L33L_L, E35D, M36I, R41K, I62V, H69K, A71V, L89I  
>1217-30701| codons 1-99
PQITLWQRPVIKVRIEGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGLVKVRQYD
QVLIEICGKKVIGTVLVGPTPANIIGRNIMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006