Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1217 | 1217-30701 | Belgium | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219E | Y181C | I2V, K20R, V35T, T39A, V60I, K102Q, K122E, D123S, I132V, I135R, S162A, K173R, Q174K, T200V, E203K, Q207E, R211E, F214L, D218E, V245Q, E248D, D250E, S251D, A272P, T286A, E291D, V292I, I293V, E297A, I329V, Q334L, F346Y, N348T, R356K, M357R, R358G, G359S, A360T, E370A, A371V, A376S, T386I, K390R, E399D |
| >1217-30701| codons 1-399 PVSPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DESFRKYTAFTVPSRNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRRKNPDIVI CQYVDDLYVGSDLEIGQHRVKIKELREHLLEWGLTTPEEKHQKEPPFLWMGYELHPDKWT VQPIQLPDKEDWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPYKTLKTGKYAKRGST HTNDVKQLTAVVQKISTESIVIWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | V11I, F53L | L10V, T12K, I13V, K14R, G16E, K20I, L33L_L, E35D, M36I, R41K, I62V, H69K, A71V, L89I |
| >1217-30701| codons 1-99 PQITLWQRPVIKVRIEGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGLVKVRQYD QVLIEICGKKVIGTVLVGPTPANIIGRNIMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |