Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1212 | 1212-30812 | Belgium | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33F | L10V, I15V, E35D, M36I, N37ND, R41K, I62V, L63P |
| >1212-30812| codons 1-99 PQITLWQRPVVTIKVGGQLKEALIDTGADDTVFEDIDLPGKWKPKLIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74V, M184V, L210W, T215F | V35T, K49R, V60I, V118I, K122Q, I135IT, S162A, T165L, K173T, Q174K, D177E, I178M, T200A, Q207E, R211RK, V245T, D250E, A272P, K277R, I293V, Y339W, K347KQ, R356K, A360T, T377L, K390R, K395KR |
| >1212-30812| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISRIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DQDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMLKILEPFRTKNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTWQIYQEPFQNLKTGKYAKMRGT HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |