<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1212 1212-30812 Belgium 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, L33F L10V, I15V, E35D, M36I, N37ND, R41K, I62V, L63P  
>1212-30812| codons 1-99
PQITLWQRPVVTIKVGGQLKEALIDTGADDTVFEDIDLPGKWKPKLIGGIGGFVKVRQYD
QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, L74V, M184V, L210W, T215F       V35T, K49R, V60I, V118I, K122Q, I135IT, S162A, T165L, K173T, Q174K, D177E, I178M, T200A, Q207E, R211RK, V245T, D250E, A272P, K277R, I293V, Y339W, K347KQ, R356K, A360T, T377L, K390R, K395KR  
>1212-30812| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISRIGPENPYNTPI
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DQDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMLKILEPFRTKNPEMVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFFTPDKKHQKEPPFLWMGYELHPDKWT
VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTWQIYQEPFQNLKTGKYAKMRGT
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQRETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006