Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1211 | 1211-30724 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | D67E | Y181C, G190GA | A98G | K20R, V35M, T39A, E44D, S68G, V118I, I135T, K173A, I178L, E203K, Q207E, H208Y, R211K, A272P, T286TA, E297K, G359S, A371V, A376C, T377M, I382T, K390R, E399D |
| >1211-30724| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDLVI CQYMDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKICMESIVTWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, L90M | L10F | T12S, I13V, L19I, K20I, L33L_L, M36I, L63P, I64V, I72V, Q92R, I93L, C95F |
| >1211-30724| codons 1-99 PQITLWQRPFVSVKIGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAVGTVLVGPTPTNIIGRNLMTRLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |