<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1211 1211-30724 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y D67E Y181C, G190GA A98G K20R, V35M, T39A, E44D, S68G, V118I, I135T, K173A, I178L, E203K, Q207E, H208Y, R211K, A272P, T286TA, E297K, G359S, A371V, A376C, T377M, I382T, K390R, E399D  
>1211-30724| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV
FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDLVI
CQYMDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKICMESIVTWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, V82T, L90M L10F T12S, I13V, L19I, K20I, L33L_L, M36I, L63P, I64V, I72V, Q92R, I93L, C95F  
>1211-30724| codons 1-99
PQITLWQRPFVSVKIGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAVGTVLVGPTPTNIIGRNLMTRLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006