Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1209 | 1209-30701 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, L33F, G73T | K20V, E35D, M36I, I62V, L63P, I64V, C67F, H69R, A71V, I72L, P79A, I85V |
| >1209-30701| codons 1-99 PQITLWQRPFITIKIGGQLVEALLDTGADDTVFEDINLPGRWKPKIIGGIGGFVKVRQYD QVPVEIFGRKVLTTVLVGATPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | Y188L | A98G | P4S, E6K, K43N, E44D, K102M, V106I, V118I, K122E, V179I, E203K, Q207DE, H208Y, R211K, K223E, L228H, Q278H, T286A, I293IV, I329L, M357T, R358K, G359S |
| >1209-30701| codons 1-399 PISSIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKMKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLLVGSDLEIGQHRTKIKELREYLWKWGFYTPDRKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |