Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1206 | 1206-30604 | Luxembourg | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K103N, Y181C | V35T, T39A, E44D, K49R, V60I, V90I, K122E, D123S, S162D, E169A, K173A, Q174K, I178L, Q207E, R211K, D237E, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297A, F346Y, R356K, M357R, G359S, A376S, T377L, K390R, Q394L, E399D | E312E* |
| >1206-30604| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISRIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILAPFRAKNPDLVI CQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPEKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTDIVPLTAEAE LELAENREILK*PVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYAKRRSA HTNDVKQLTEAVQKISLESIVIWGKTPKFRLPILKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50V, I54V, V82A | L24I, L33F, Q58E | L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63Q, H69Y, L89M |
| >1206-30604| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVFEDINLPGKWKPKLIGGVGGFVKVKEYD NVQIEICGYKAIGTVLVGPTPANIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |