<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1202 1202-30702 Belgium 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L33F, N83D I13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93L  
>1202-30702| codons 1-99
PQITLWQRPLVTVKIEGQLREALLDTGADDTVFEDIDLPGKWKPKMIGGIGGFVKVKQYD
QINIEICGKRAIGTVLVGPTPADIIGRNIMVQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215F K219E K103KN   V35T, K43R, T69N, D121H, K122E, D123E, I142V, K173S, Q174K, D177E, T200A, Q207A, R211K, V245K, T286A, E291D, V292I, I293V, E297R, A304E, E312N, I329V, G335D, R356K, M357K, R358K, G359S, A360T, A371V, I375V, A376T, T377L, K390R, E396D  
>1202-30702| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEREGKISKIGPENPYNTPV
FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
HEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELRAHLLKWGFFTPDEKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTREAE
LELEENREILKNPVHGVYYDPSKDLIAEVQKQGQDQWTYQIYQEPFKNLKTGKYAKKKST
HTNDVKQLTEVVQKVTLESIVIWGKTPKFRLPIQKDTWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006