<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1201 1201-30623 Belgium 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L10F, L33I, K43T, N88D T4P, K20R, E35D, M36I, N37D, I62V, L63P, C67L, A71V, I72L  
>1201-30623| codons 1-99
PQIPLWQRPFVTIKIGGQLREALLDTGADDTVIEDIDLPGRWTPKLIGGIGGFVKVRQYD
QVPIEILGHKVLGTVLVGPTPANIIGRDLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70KR, L74LI, M184V, L210W, T215F K219Q K103KNRS, G190A   K20R, V35I, V60I, V118I, K122P, I135V, S162SDGN, K166KR, Q174R, D177E, V179I, I195L, G196E, T200A, E203V, Q207E, H208HY, R211K, L228H, K277R, Q278E, P294T, E297R, I326IV, Q334L, K350KR, G359S, A371V, A376S, T386TI, E399D  
>1201-30623| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKRNPEIII
YQYVDDLYVASDLELEQHRAKIVELREYLWKWGFFTPDQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGTKALTEVITLTREAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDVKQLTEVVQKISTESIVIWGKIPKFKLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006