Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1201 | 1201-30623 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, L33I, K43T, N88D | T4P, K20R, E35D, M36I, N37D, I62V, L63P, C67L, A71V, I72L |
| >1201-30623| codons 1-99 PQIPLWQRPFVTIKIGGQLREALLDTGADDTVIEDIDLPGRWTPKLIGGIGGFVKVRQYD QVPIEILGHKVLGTVLVGPTPANIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74LI, M184V, L210W, T215F | K219Q | K103KNRS, G190A | K20R, V35I, V60I, V118I, K122P, I135V, S162SDGN, K166KR, Q174R, D177E, V179I, I195L, G196E, T200A, E203V, Q207E, H208HY, R211K, L228H, K277R, Q278E, P294T, E297R, I326IV, Q334L, K350KR, G359S, A371V, A376S, T386TI, E399D, A400T |
| >1201-30623| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKRNPEIII YQYVDDLYVASDLELEQHRAKIVELREYLWKWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGTKALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKISTESIVIWGKIPKFKLPIQKETWDT |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |