Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1862 | 1862-30925 | Mexico | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70KR | V118I, K122E, I135T, S162C, Q174L, V179I, G196E, Q207H, R211K, F214L, L228R |
| >1862-30925| codons 38-246 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKLNPDIIIYQYMDDLYVGSDLEIEQHRTKIEELRHHLLKWGLTTP DKKHQKEPPFRWMGYELHPDKWTVQPIVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54IV | N88D | T12S, I13IV, L19I, K20KT, E35ED, N37NS, R41RK, L63P, I66IF, K70R, A71V, T74TS, V77I |
| >1862-30925| codons 4-99 TLWQRPLVSVKIGGQITEALLDTGADNTVLEDMSLPGKWKPKMIGGIGGFVKVRQYDQIP IEFCGHRVIGSVLIGPTPVNIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |