<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1849 1849-30930 Mexico 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82S L24I, Q58QE L10I, I15IV, K20R, E35ED, M36I, R41K, D60DE, I62V, L63LASV, I64V, A71AV, T74S, I93L  
>1849-30930| codons 4-99
TLWQRPIVTIKVGGQLREALIDTGADDTVLEDINLPGKWKPKLIVGIGGFVKVREYEQVV
VEICGHKVIGSVLVGPTPSNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184MV, T215F V75M, K219Q K101E, Y181C, G190A A98G, V108I T39A, K43Q, V118I, K122E, D123E, I135T, I167IV, D177G, G196Q, T200TA, Q207E, H208Y, R211RK, D218E, E224D, L228H, D237E N54I
>1849-30930| codons 38-247
CAELEQEGKISKIGPEIPYNTPVFAIKKKNSTRWRKIMDFRELNKRTQDFWEVQLGIPHP
GGLEKKKSVTILDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKVLEPFRKQNPGIVICQYVDDLYVASDLEIQQHRAKIEELREYLLKWGFFTP
EQKHQKDPPFHWMGYELHPEKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006