Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1849 | 1849-30930 | Mexico | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82S | L24I, Q58QE | L10I, I15IV, K20R, E35ED, M36I, R41K, D60DE, I62V, L63LASV, I64V, A71AV, T74S, I93L |
| >1849-30930| codons 4-99 TLWQRPIVTIKVGGQLREALIDTGADDTVLEDINLPGKWKPKLIVGIGGFVKVREYEQVV VEICGHKVIGSVLVGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75M, M184MV, T215F | K219Q | K101E, Y181C, G190A | A98G, V108I | T39A, K43Q, V118I, K122E, D123E, I135T, I167IV, D177G, G196Q, T200TA, Q207E, H208Y, R211RK, D218E, E224D, L228H, D237E | N54I |
| >1849-30930| codons 38-247 CAELEQEGKISKIGPEIPYNTPVFAIKKKNSTRWRKIMDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTILDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKVLEPFRKQNPGIVICQYVDDLYVASDLEIQQHRAKIEELREYLLKWGFFTP EQKHQKDPPFHWMGYELHPEKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |