<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1846 1846-30930 Mexico 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V, L210W, T215Y K219N   F227L S48E, V118VI, I142V, S162A, I202V, R211K, L228H, V245E  
>1846-30930| codons 38-247
CTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP
AIFQASMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTP
DNKHQKEPPLHWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M V11VI, K43T, G73A, L89V L10V, K14GR, I15V, G16GW, Q18QH, K20LM, E21Q, M36MI, R41K, G51A, K55KR, D60DE, I62V, L63P, C67CF, K70KR, A71V, I72L, I85V  
>1846-30930| codons 4-99
TLWQRPVITIRVWGHLMQALLDTGADDTVLEEINLPGKWTPKIIGGIAGFVRVRQYEQVP
IEIFGHRVLATVVVGPTPANIVGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006