Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1821 | 1821-30924 | Mexico | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | L10I, I13V, K14R, I15V, K20M, E35D, M36V, N37NS, I62V, L63P, A71V, I93L |
| >1821-30924| codons 4-99 TLWQRPIVTVRVGGQLMEALLDTGADDTVLEDVSLPGRWKPKMIGGIGGFIKVRQYDQVP IEICGHKVISTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | Y181C | T39A, K64KR, K122E, D123E, I135T, T200A, Q207E, R211K, K223Q, L228R, Q242L |
| >1821-30924| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIRKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTP DKKHQQEPPFRWMGYELHPDKWTVLPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |