Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1180 | 1180-30922 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | F53L | L10I, I15V, K20I, E35N, M36I, R41K, R57K, Q61N, L63P, I72IV, T74S, V82I, I85V, L89LI |
| >1180-30922| codons 4-99 TLWQRPIVTIKVGGQLIEALLDTGADDTILENINLPGKWKPKIVGGIGGLMKVKQYDNIP IEICGHKAVGSVLVGPTPINIVGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184MV, T215F | V75I | K103N | T39TA, V60I, V90I, K101R, K122E, D123E, I132L, I135V, E138G, S162C, H221Y, L228LHIN, I244V |
| >1180-30922| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKIIDFRELNKRTQDFWEIQLGIPHP AGLRKNKSVTVLDVGDAYFSVPLDEEFRKYTAFTLPSVNNGTPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTP DKKYQKEPPFNWMGYELHPDKWTVQPVVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |