Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1179 | 1179-30917 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MIL, I47IV, I54L, I84IV, L90LM | L24LI, L33F | L10IV, I15IV, K20KR, E35D, M36I, N37NT, R41K, R57K, Q61N, L63P, H69Y, I72T |
| >1179-30917| codons 4-99 TLWQRPVVTIKVGGQLREALIDTGADDTIFEDITLPGKWKPKLVGGIGGFLKVKQYDNIP IEICGYKATGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | V60VI, K101KQ, K103R, V118I, K122E, I135T, R211K, F214L, V245M | L120L* |
| >1179-30917| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKRKSVTVLDVGDAYFSIP*DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLFTP DQKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |