Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1059 | 1059-30825 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, Y115F, Q151M, M184V, T215F | V75I, F77L, F116Y, K219Q | K101E, Y181C | V108I | V106VI, V118I, K126KE, I135T, Q174E, E203D, H208HP, R211K, F214L, L228H, V245T | W153WC |
| >1059-30825| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLEKKKSITILDVGDAFYSIPLDKDFREYTAFTIPSTNNETPGIRYQYNVLPMGCKGSP AIFQSSMTKILEPFRKENPDIVICQYVDDLYVGSDLEIGQHRTKIDELRQPLLKWGLFTP DQKHQKEPPFHWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V | L24I, L33F, K43T | L10I, I13IV, I15V, L19Q, K20R, E35D, M36I, N37E, R41K, K55N, R57K, I62V, I64V, E65D, A71V, Q92K |
| >1059-30825| codons 4-99 TLWQRPIVTVKVGGQQREALIDTGADDTIFEDIELPGKWTPKIVGGIGGFLNVKQYDQVL VDICGHKVIGTVLVGPTPVNVIGRNLLTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |