Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1054 | 1054-30701 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62V, V75IL, F77FL, F116Y | K103KN, G190A | P225H | K49R, E53D, K102Q, K104R, K122E, D123E, E169D, P170PL, D177E, I202V |
| >1054-30701| codons 38-247 CTEMEKEGKISRIGPDNPYNTPVFVIKKKDSTKWRKLLDLRELNKRTQDFWEVQLGIPHP AGLKQNRSVTVLDVGDAFYSVPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILDLFRKQNPEIVIYQYVDDLYVASDLEIGQHRTKVEELRQHLLRWGFTTP DKKHQKEHPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, L76V, L90M | L89V | L10I, I15V, K20T, E35G, M36I, N37D, I62V, L63P, H69K, A71AV, V77I, V82I, I85V |
| >1054-30701| codons 5-99 LWQRPIVTIKVGGQLTEALLDTGADDTVLEGIDLPGRWKPKIIGGIGGFVKVRQYDQVPI EICGKKVIGTVVIGPTPINIVGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |