Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1121 | 1121-30728 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L90M | L10R, T12P, K14KR, E35D, M36I, I62IV, L63P, I64V, I72V, V77I |
| >1121-30728| codons 4-99 TLWQRPRVPIRIGGQLKEALLDTGADDTVLEDINLPGRWKPKLIGGIGGFIKVRQYDQVP VEICGHKAVGTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215F | K103N | T200A, I202V, E204D, I244V |
| >1121-30728| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKVEDLRQHLLRWGFFTP DKKHQKEPPFLWMGYELHPDKWTVQPVVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |