Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1103 | 1103-30708 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A, L90M | L33F, K43T | L10I, I13V, I15V, G16E, K20M, E35H, M36L, R41K_K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, L89LM, I93L |
| >1103-30708| codons 4-99 TLWQRPIVTVKVEGQLMEALLDTGADDTVFEHLNLPGKWTPKLIGGIGGFVRVKQYDNIS IDICGHKVIGSVVVGPTPANIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67NY, K70R, Q151M, T215F | K219E | K103N, Y181V | V108I | V60I, T69N, W88S, K101Q, K102Q, L109I, D123E, I135V, S162W, I202V, F214FL, D218E, L228H |
| >1103-30708| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKYSNRWRKLVDFRELNKRTQDFSEVQLGIPHP AGLQQNKSVTIIDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSP AIFQWSMTKILEPFRKQNPDIVIVQYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |