Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1027 | 1027-31124 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I47IV, I54V, V82A, L90M | L33LF, F53L | L10IV, I15V, K20R, E34EV, E35D, M36I, N37NS, R41K, D60DE, Q61DN, I62V, L63P, A71AV, T74S, L89LM, Q92QK |
| >1027-31124| codons 4-99 TLWQRPVVTIKVGGQLREALLDTGADDTVFVDISLPGKWKPKIVGGIGGLVKVRQYENVP IEICGHKVIGSVLVGPTPANIIGRNMMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | A62AV, K219N | K101E, Y181C, G190A | T39K, K43E, E44ED, K49KR, A98S, V118I, K122E, I135R, T200A, E203K, Q207D, K223Q |
| >1027-31124| codons 38-247 CKELEEDGKISRIGPENPYNTPVFVIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP SGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRAKIKELRDHLWRWGFYTP DNKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |