<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1027 1027-31124 Argentina 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 20

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I47IV, I54V, V82A, L90M L33LF, F53L L10IV, I15V, K20R, E34EV, E35D, M36I, N37NS, R41K, D60DE, Q61DN, I62V, L63P, A71AV, T74S, L89LM, Q92QK  
>1027-31124| codons 4-99
TLWQRPVVTIKVGGQLREALLDTGADDTVFVDISLPGKWKPKIVGGIGGLVKVRQYENVP
IEICGHKVIGSVLVGPTPANIIGRNMMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y A62AV, V75T, K219N K101E, Y181C, G190A   T39K, K43E, E44ED, K49KR, A98S, V118I, K122E, I135R, T200A, E203K, Q207D, K223Q  
>1027-31124| codons 38-247
CKELEEDGKISRIGPENPYNTPVFVIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP
SGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRAKIKELRDHLWRWGFYTP
DNKHQQEPPFLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006