Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1025 | 1025-30623 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, I54IL | N88ND | K14NS, I15V, L19I, K20T, E35D, M36MI, D60E, L63P, A71IV |
| >1025-30623| codons 4-99 TLWQRPLVTISVGGQITEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFLKVRQYEQIP IEICGHKVIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, K70R, T215F | D67G, K219Q | K101E, Y181C | V108I | K64R, A98S, D123E, I135V, I142V, K166R, D177E, I178L, Q207E, L228R |
| >1025-30623| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIRKKGSDRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLEKKKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPELVICQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTP DQKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |