Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1039 | 1039-30619 | Argentina | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, L90M | F53L, G73S | I15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, H69Y, A71V, T74TS, I85IV |
| >1039-30619| codons 4-99 TLWQRPLVTIKVGGQIREALLDTGADDTVLEDINLPGKWKPKMIGGIGGLVKVKQYDNVP IEICGYKVISSVLVGPTPTNIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | K101E, Y181C, G190A | K49R, V60I, K66R, I135T, S162A, H208Y, R211K, D218E, L228HR |
| >1039-30619| codons 38-247 CTELEKEGKISRIGPENPYNTPIFAIKKRNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELRQYLLKWGFFTP EQKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |