Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1035 | 1035-30618 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82A | L10I, L19I, E35D, N37S, L63P, H69R, A71V |
| >1035-30618| codons 4-99 TLWQRPIVTIKIGGQIKEALLDTGADDTVLEDMSLPGRWKPKIIVGIGGFTKVRQYDQIP IEICGRKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, V75T, M184MV | A62V | K101KPQT, K103N | K49KR, D123E, D177E, I202V | S68SDGN, Q242Q* |
| >1035-30618| codons 38-247 CTEMEKEGKISRIGPENPYNTPVFVIKRKDNTKWRKLTDFRELNKRTQDFWEVQLGIPHP AGLTKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTV*PIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |