Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1032 | 1032-31009 | Argentina | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 4 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12N, L19V, K20I, M36I, R41K, L63T, I72V, T74S, Q92QH |
| >1032-31009| codons 4-99 TLWQRPLVNIKIGGQVIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQIT IEICGHKAVGSVLVGPTPVNIIGRNLLTHIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103KN | K49KR, V60I, D121H, K122E, I135T, I178M, G196E, V245M |
| >1032-31009| codons 38-247 CTEMEKEGKISRIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |